John Fitzgerald Kennedy lived in Brookline for ten years. In 1927, the family moved to 5040 Independence Avenue in Riverdale, Bronx, New York City; then two years later, moved to Bronxville, New York. Kennedy was the thirty-fifth President of the United States. He was assassinated at 12:30 p.m. Central Standard Time on Friday, November 22, 1963, in Dealey Plaza, Dallas, Texas. Kennedy was fatally shot while traveling with his wife Jacqueline, Texas governor John Connally, and the latter's wife, Nellie, in a Presidential motorcade.

A member of the Democratic Party, Kennedy won election to the House of Representatives in 1946. Over the next couple of years he established himself as a loyal supporter of Harry S. Truman. In Congress he advocated progressive taxation, the extension of social welfare and more low-cost public housing. He was also a leading opponent of the Taft-Hartley Bill. Kennedy took a strong interest in foreign policy and in 1951 toured Europe visiting Britain, France, Italy, Spain, Yugoslavia and West Germany. On his return he told the Senate Committee on Foreign Relations that the United States should maintain its policy of helping to defend Western Europe. However, he argued that the countries concerned should contribute more to the costs of the operation. In the autumn of 1951 Kennedy visited the Middle East, India, Pakistan, Indochina, Malaya and Korea. An opponent of colonial empires, Kennedy urged that France should leave Algeria. He also argued for increased financial aid to underdeveloped countries.